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Research


ABSTRACTS: 

 

Depression is often diagnosed using the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria. We propose how certain lifestyle choices and non-modifiable factors can predict the development of depression. We identified 10 cause categories (hits or “blows” to the brain) and theorize that four or more active hits could trigger a depression episode. Methods. A sample of 4271 participants from our community-based program (70% female; ages 17-94 years) was assessed at baseline and at the eighth week of the program using a custom test. Ten cause categories were examined as predictors of depression are (1) Genetic, (2)Developmental, (3)Lifestyle, (4)Circadian Rhythm, (5)Addiction, (6)Nutrition, (7)Toxic, (8)Social/Complicated Grief, (9)Medical Condition, and (10)Frontal Lobe. Results. The relationship between the DSM-5 score and a person having four hits categories in the first program week showed a sensitivity of 89.98 % (95% CI: 89.20 % - 90.73%), specificity 48.84% (CI 45.94-51.75) and Matthew Correlation Coefficient (MCC) .41 . For the eight-week test, the results showed a sensitivity 83.6% (CI 81.9-85.5), specificity 53.7% (CI 51.7-55.6) and MCC .38. Overall, the hits that improved the most from baseline after the eighth week were: Nutrition (47%), Frontal lobe (36%), Addiction (24%), Circadian rhythm (24%), Lifestyle (20%), Social (12%) and Medical (10%). Conclusions. The Nedley four-hit hypothesis seems to predict a depressive episode and correlates well with the DSM-5 criteria with good sensitivity and MCC but less specificity. Identifying these factors and applying lifestyle therapies could play an important role in the treatment of depressed individuals.

 

 

Educational Program Decreases Alcohol Consumption

N Nedley, FE Ramirez, "An educational program decreases alcohol consumption of participants." Presented in the Australian Professional Society on Alcohol & other Drugs meeting in Perth, Australia 2015.

 

Residential Program Weaning Protocol for Benzodiazepine

F Ramirez, L Villegas, & N Nedley (2016). "Protocol to Wean Alprazolam and Lorazepam with the Help of a 10 Day Residential Program." American Journal on Addictions 25 (4), 341-342.


Emotional Intelligence in Persons Involved in Sexual Relationships Outside Marriage

FE Ramirez, RD Gallant, & N Nedley. (2016). 089 "Emotional Intelligence in Persons Involved in Sexual Relationships Outside Marriage." The Journal of Sexual Medicine, 13(5), S43.


Eight-week Program Improves Depression with Lifestyle Changes

N Nedley, FE Ramirez "Eight-Week Depression Program Improves Depression With Lifestyle Changes And Exercise Therapy." Presented in the 7th Edition of the Muscletech Network Workshop and 4th Congress of the European College of Sports and Exercise Physicians meeting in Barcelona, Spain 2015


Effect of Eight-week Program on Individuals Exposed to Fish Toxins

N Nedley, FE Ramirez, S Ramirez, "Effect of 8-week program on individuals exposed to fish environmental toxins." Drug Metabolism Reviews 47 (s1), 28-157.


Lavender Oil for Depression

N Nedley, FE Ramirez, " Use of oral lavander oil for anxiety in a depression medical residential program." Journal of the International Neuropsychological Society 22 (s1), 151


Lead Exposure and Mental Health

FE Ramirez, P Grilo, N Nedley, "Lead Exposure and Mental Health." Nedley Journal of the International Neuropsychological Society 22 (s1), 153


Community Program Improvement of Depression in Individuals with Hepatitis C

N Nedley, FE Ramirez, & S Olafsson. Su1409 "Eight-Week Community Based Program Is Associated With at Least Some Improvement of Depression in the Vast Majority of Individuals With Hepatitis C." Gastroenterology 148.4 (2015): S-501. 


Eight-week Program Decreases Usage of Benzodiazepines

F Ramirez, & N Nedley. "Eight-week Depression Program Decreases Usage of Benzodiazepines." The American Journal on Addictions 24 (1), 65.


Plant Based Diet Improves Lipid Profile in All Participants

N Nedley, FE Ramirez, "Adoption of plant based diet improves lipid profile in all participants". Presented in the 6th International Congress on Vegetarian Nutrition meeting in 2013, Loma Linda, CA


Consumption of Energy Rich Nutrients in Depression Individuals

FE Ramirez, F Li, L Ivy, N Nedley. "Energy-Rich nutrients and hemoglobin A1c among depressed individuals" For the meeting International Conference on Diabetes, Washington, DC, 2014


Sexual Abuse Increases Risk of Addictive Behaviors 

F Ramirez, & N Nedley. (2016). 088 "Sexual Abuse Increases Risk of Addictive Behaviors." The Journal of Sexual Medicine, 13(5), S42-S43.


Sexual Behavior May Influence Depression

F Ramirez, & N Nedley. (2016). 087 "Sexual Behavior Seems to Influence Depression." The Journal of Sexual Medicine 13 (5), S42.

 

Vitamin D Supplementation Improves Depression in a Residential Program

F Ramirez, N Nedley "Vitamin D supplementation improves depression in a residential program" Conference paper presented at the 14th Annual Natural Supplements: An Evidence-Based Update in San Diego California.


 Violation of Conscience is Related to Worse Mental Health Among Geriatrics

N Nedley, FE Ramirez& D Byrkit, P9-095 "Violation Conscience is Related to Worse Mental Health Among Geriatrics." Journal of the International Neuropsychological Society Volume 23 (2017), S 1.

 

 Nicotine Increases Depression and Anxiety

N Nedley, FE Ramirez, S Serrano, L Hofer-Draper, "Nicotine Increases Depression and Anxiety". Drug Metabolism and Pharmacokinetics 32 (1), S107.


Spiritual Material and Sexual Relationships Outside Marriage

F Ramirez, N Nedley, D Byrkit "Spiritual Material and Sexual Relationships Outside Marriage" The Journal of Sexual Medicine 14 (2), e91. 

 

 Eight-week Community Based Program Improves Anxiety of Hepatitis C Positive Individuals

N Nedley, FE Ramirez,"Eight-week community based program improves anxiety of hepatitis c positive individuals." Poster presentation given at the Americas Hepato-Pancreato-Biliary Association 2017 Annual meeting in Miami March 31-April 2, 2017.

 

Self Reported Vitamin B12 Intake and Vitamin B12 Deficiency Among Vegetarians

N Nedley, FE Ramirez, E Anasi, K Jacobo,"Self reported vitamin B12 intake and vitamin B12 deficiency among vegetarians." Presented in the el 14th Annual Scripps Health: Natural Supplements congress in San Diego 2016.

 

 Not Growing Up With Both Parents May Affect Mental Health

N Nedley, FE Ramirez "Not Growing Up With Both Parents May Affect Mental Health." Presented at Harvard's University New England Science Symposium in April 2016,

 

Morbid thoughts decrease on individuals with concussion history after an 8-week educational program

N Nedley, FE Ramirez, "Morbid thoughts decrease on individuals with concussion history after an 8-week educational program." CME granting Oral presentation given at the 12th World Congress on Brain Injury Congress (IBIA) in New Orleans March 29-April 1, 2017.

 

 Lifestyle Interventions that Benefit the Heart Also Improve Depression Among Geriatrics

N Nedley, FE Ramirez"Lifestyle Interventions that Benefit the Heart Also Improve Depression Among Geriatrics" Circulation 2017;135:AP018. 

 

 Lavender Oil Supplements and Sleep

N Nedley, FE Ramirez, L Hofer-Draper, K Jacobo, "Lavender oil supplements and sleep." Presented in the 14th Annual Scripps Health: Natural Supplements congress in San Diego 2016. Will be published in the journal of Alternative and Complementary Medicine. *Winner of third best study in the meeting.


 Lifestyle Educational Intervention Increases Folate Intake and Improves Depression

F Ramirez, N Nedley "Lifestyle Educational Intervention Increases Folate Intake and Improves Depression" Conference paper presented at the 14th Annual Natural Supplements: An Evidence-Based Update in San Diego California. 

 

 Emotional Intelligence On Depressed Individuals Is Improved In 8 Weeks

FE Ramirez, K Antuna, & N Nedley. (2016). "Emotional Intelligence On Depressed Individuals Is Improved In 8 Weeks". Biological Psychiatry 79(9S):126S · May 2016

 

Emotional Intelligence Improves in 8 weeks in Participants with history of Head Injury 

N Nedley, FE Ramirez, "Emotional Intelligence Improves in 8 weeks in Participants with history of Head Injury." CME granting Oral presentation given at the 12th World Congress on Brain Injury Congress (IBIA) in New Orleans March 29-April 1, 2017.

 

Effects of an Educational Program on depressed Postmenopausal Participants

 

F Ramirez, N Nedley, C Krueger "Effects of an Educational Program on depressed Postmenopausal Participants." The Journal of Sexual Medicine 14 (2), e94.


Depressed Individuals May Not Be Aware Of Their Own Dyslipidemia

FE Ramirez, J Siebold, K Antuna, A Sanchez, N Nedley, "Depressed Individuals May Not Be Aware Of Their Own Dyslipidemia." Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36:A272.

 

 Eight-week lifestyle education improves depression of stroke participants

F Ramirez, N Nedley, & V Tudor, (2016). "Eight-week lifestyle education improves depression of stroke participants." Brain Injury 30 (5-6), 705.

 

Not Growing Up With Both Parents May Affect Mental Health

N Nedley, FE Ramirez"Not Growing Up With Both Parents May Affect Mental Health." Presented at Harvard's University New England Science Symposium in April 2016,


 Eight Week Lifestyle Education Program Improves Concentration on Participants With Reduced Blood Flow to the Brain

N Nedley, FE Ramirez, "Eight Week Lifestyle Education Program Improves Concentration on Participants With Reduced Blood Flow to the Brain." Journal of Clinical Lipidology11(3), 824-825.

 

 Animal Products Tend to Increase Hemoglobin A1c Among Depressed Individuals

FE Ramirez, J Siebold, N Nedley, K Antuna, A Sanchez, P Grilo. "Animal Products Tend to Increase Hemoglobin A1c Among Depressed Individuals." Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36:A271.



PRESS RELEASE: 11-September-2017


Positive correlation discovered between hemoglobin A1c and depression in individuals.


Nedley Clinic confirmed findings that linked energy-dense foods such as meat (excluding fish and cheese) consumption to levels of hemoglobin A1c in clinically depressed individuals.

 

A new study presented at the International Conference on Diabetes highlighted diabetic individuals with comorbid depression. An analysis of the study looked at 309 participants of a 10-day plant based residential depression recovery program. During the 10-day program, their Beck Depression Inventory scores plummeted from an average of 24 (Moderate to Severe Major Depression) down to an average of 6 (no Depression). The groups A1c was positively correlated to their before and after Beck Depression Inventory scores. It was found that compared to no meat intake, consumption of meat at least twice a day was associated with higher hemoglobin A1c levels.


Neil Nedley, MD, states “Diabetes patients with comorbid depression can have less self-care and treatment adherence, glycemic control, and increased mortality. These intertwined symptoms are often termed ‘diapression’. Treatment is challenging because depression can increase diabetes symptoms, decrease self-care behavior, and increase disability rates.”


"Energy-rich foods can induce a diabetic state' in individuals. This has not been well studied in depressed individuals. Nevertheless, we can confirm a positive correlation,” says Francisco Ramirez, MD.


The 10-day plant-based residential depression treatment program teaches participants various lifestyle habits such as nutrition, physical exercise, circadian rhythms, bright light, sleep, avoiding negative distorted thought, enhancing frontal lobe function, and making and staying with positive lifestyle choices. The program includes doctor, psychiatric, and spiritual counseling visits. Each participant completes depression and anxiety assessment tests and questionnaires to provide a baseline. Hemoglobin A1c was assessed through blood samples on the first day of their residence. After completing the 10-day program, a final 75 item questionnaire is given including follow up doctor assessment, psychiatric counseling, and blood work to chart successful progress.


"This approach to comorbid diabetes and depression can have profound life altering benefits. Not only will patients live longer, but will live happier and healthier lives. This methodology is far cheaper than traditional diabetes and depression treatment modalities" said Neil Nedley, MD.


International Conference on Diabetes, presented July 2014.
Further information or press inquiries may be obtained by contacting

Communications and Media Relations

Cami Martin, cami@drnedley
or Francisco Ramirez, MD, eramirez@weimar.edu 


PRESS RELEASE: 30-August-2017

  

Benzodiazepine abuse decreases after low-cost community depression recovery program.

 

Nedley Clinic discovers that not only is there a decrease in depressive symptoms but a distinct reduction in benzodiazepine use after a low-cost 8-week community depression recovery program.  

 

The findings were presented at the American Academy of Addiction Psychiatry (AAAP) 25th Annual Meeting. An observational study of more than 300 participants from 7 countries who had moderate depression and who acknowledged use of benzodiazepines at baseline showed significantly lowered depression scores at the end of the 8-week program. Plus, 13% of those who had been taking benzodiazepines on an irregular basis stopped using them altogether, and 24% of those who had been taking them more than twice a month decreased or stopped use.

 

"Our focus in the program isn't on benzodiazepines, but this was a nice side effect," lead author Francisco Ramirez, MD. “Emphasis is also given to overcoming the usage of substances that can create an addictive relationship,” Dr. Ramirez adds.

 

The study's eight 2-hour, once-weekly, lifestyle-focused depression treatment program teaches participants about exercise, rest, and nutrition, as well as temperance and the use of spiritual resources to improve depression and anxiety. They watch pre-recorded presentations of Neil Nedley, MD, presenting materials on mental health and the science linked to improving depression and anxiety. Participants are taught various lifestyle habits such as nutrition, physical exercise, circadian rhythms, bright light, sleep, avoiding negative distorted thought, enhancing frontal lobe function, and making and staying with positive lifestyle choices. After the presentation, participants are divided into professionally facilitated small groups where the material presented and how it can be incorporated into their lives is discussed.  After completing the program, a final 75 item questionnaire is given to complete their assessment.

 

"This study demonstrates that an 8-week community-based depression recovery program can be an effective tool to help participants overcome the usage of benzodiazepines," said Neil Nedley, MD.

 

 

American Academy of Addiction Psychiatry (AAAP) 25th Annual Meeting: Abstract 21, presented December 5, 2014.

 

 

Further information or press inquiries may be obtained by contacting

Communications and Media Relations

Cami Martin, cami@drnedley

or Francisco Ramirez, MD, eramirez@weimar.edu

 

PRESS RELEASE: 3-June-2016

 

Researchers map elevated emotional intelligence after low-cost depression recovery program

 

A new study from Nedley Clinic and Weimar Institute shows the important role a low-cost eight-week depression recovery program has on increasing the emotional intelligence scores of the participants.

 

The study presented at the Society of Biological Psychiatry May 13, 2016 in Atlanta, Georgia is revealing the associations between those attending an eight-week depression program and an increase in their emotional intelligence. Neil Nedley, MD, and Francisco E. Ramirez, MD, observed that at the completion of the program over 20% of participants were now classified as having very high emotional intelligence compared to less than 9% at the start of the program. Also noted that the 5,621 individuals in nine countries who finished the program, improved their emotional intelligence score by an average of nine points.

 

Neil Nedley, MD, remarked, “This is a common sense assumption which science is only now beginning to demonstrate. The implications for giving people a reason to change that can bring healing as well as assisting them to excel in their future lives by improving their emotional intelligence cannot be overstated.”

 

Improved emotional intelligence brings immediate benefits to emotional health, relationships, work, and the quality of life. Those with high emotional intelligence are able to manage their emotions and better understand emotions in others. “Increased job satisfaction, promotions, and stronger marriages, are just some of the benefits we have seen,” says Francisco E. Ramirez, MD.

 

Incoming participants take a 75 item questionnaire to gauge depression, anxiety and emotional intelligence. Participants then take part in eight two-hour meetings held one night a week. They watch pre-recorded presentations of Neil Nedley, MD, presenting materials on mental health and the science linked to improving depression and anxiety. After the presentation participants are divided into professionally facilitated small groups where the material presented and how it can be incorporated into their lives is discussed.  After completing the program, a final 75 item questionnaire is given to complete their assessment.

 

Neil Nedley, MD, states “One part of the series has an emphasis on Cognitive Behavioral Therapy, which focuses on the relationship between thoughts, feelings and behaviors. It involves a practical skills approach that enables participants to tackle their problems by harnessing their emotional intelligence.”

 

This new study reveals that significant elevations in their emotional intelligence and using Cognitive Behavioral Therapy as taught by this program can further propel participants lives in positive directions.

 

The research will be published later this year in the Journal of Biological Psychology.

  

Further information or press inquires may be obtained by contacting

Communications and Media Relations

Cami Martin, cami@drnedley.com

or Francisco Ramirez, MD, eramirez@weimar.edu 

By web at:

www.nedleyhealthsolutions.com

www.nedleydepressionrecovery.com